Information regarding Cystic Fibrosis, the types of research being performed to finds its cure.  Learn more about gene therapy, and treatments for Cystic Fibrosis as well as volunteering opportunities.
The Center has many research laboratories dedicated to finding a cure for Cystic Fibrosis.  Meet the different lab directors, their lab members and the laboratories particular focus.
A complete list of publications from the Centers lab directors that are related to Cystic Fibrosis.
Apply for open positions at the Cystic Fibrosis Research Development Center.
Visit other websites of organizations and associations affiliated with Cystic Fibrosis.
Letter from the Director addressing the Centers continued plan for the future.






















Pamela L. Zeitlin, M.D., Ph.D.

Pam Home | Publications | Book Chapters | Lab Members



Pamela L. Zeitlin, M.D., Ph.D.
Professor of Pediatrics
The Johns Hopkins University School of Medicine
Baltimore, MD 21205


Pamela Zeitlin


Zeitlin, P.L, Crawford,I., Huganir,R., Lu,L., Cohen,M., Donowitz, M., Montrose,M., Woel, S., Trapnell, B., Crystal, R., Cutting,G., Gruenert, D., Maloney, P., Guggino, W. B. (1992) CFTR protein expression in cultured and secretory epithelia. Proc.Natl.Acad.Sci.USA 89:344-347.

  Egan, M.E., Zeitlin, P.L., Guggino, W.B. (1992) Modulation of ion transport in tracheal epithelium by lipoxygnease metabolites. Amer.J.Resp.Cell Molec.Biol. 7:500-506.
  Wiebke, J., Zeitlin, P.L., Guggino, W.B., (1992) Effect of hypoxia on endothelin-1 production by pulmonary vascular endothelial cells. Biochim.Biophys.Acta 1134:105-111.

Egan, M., Flotte T., Afione, S., Solow, R., Zeitlin, P.L., Carter, B.J., Guggino, W.B. (1992). Correction of defective PKA regulation of outwardly rectifying chloride channels by insertion of normal CFTR into CF airway cells. Nature.358:581-584.

  Flotte TR, Solow R, Owens RA, Afione S, Zeitlin PL, Carter BJ. Gene expression from adeno-associated virus vectors in airway epithelial cells. Amer J Resp Cell Mol Biol 1992; 7:349-356.

Kunzelman K, EM Schwiebert, PL Zeitlin, WL Kuo, BA Stanton, and DC Gruenert. (1993) An immortalized cystic fibrosis tracheal epithelial cell line homozygous for the AF508 CFTR mutation. Am. J. Respir. Cell Mol. Biol. 8:522-529.


Piazza-Carroll T, I McIntosh, ME Egan, PL Zeitlin, G Cutting, and WB Guggino. Transmembrane mutations alter the channel characteristics of the cystic fibrosis transmembrane conductance regulator expressed in Xenopus oocytes. Cell. Physiol. Biochem. 1994; 4:10-18.

  Flotte TR, SA Afione, and PL Zeitlin. Adeno-associated virus vector gene expression occurs in non-dividing cells in the absence of vector DNA integration. (1994) Am J Respir Cell Mol Biol. 11:517-521.
  Murray CB, MM Morales, TR Flotte, SA McGrath-Morrow, WB Guggino and PL Zeitlin. C1C2: A developmentally-dependent chloride channel expressed in the fetal lung and downregulated after birth (1995). Am. J. Respir. Cell Mol. Biol. 12:597-604.
  Zeitlin PL, Chu 5, C Conrad, U McVeigh, K Ferguson, TR Flotte, and WB Guggino. Alveolar stem cell transduction by an adeno-associated viral vector. (1995) Gene Therapy, 2:623-631.
  Guay-Broder C, KA Jacobson, S Barnoy, ZI Cabantchik, WB Guggino, PL Zeitlin, RI Turner, L Vergara, 0 Eidelman, and HB Pollard. Al receptor antagonist 8-cyclopentyl-1 ,3-dipropylxanthine selectively activates chloride efflux from human epithelial and mouse fibroblast cell lines expressing the cystic fibrosis transmembrane regulator AFSO8 mutation, (1995) Biochemistry 34(28):9079-87.

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